Article
Frequently elevated content of immunochemically defined wild-type p53 protein in colorectal adenomas.
Oncogene - 1 Oct 1993
Tominaga O, Hamelin R, Trouvat V, Salmon R J, Lesec G, Thomas G, Remvikos Y
Abstract excerpt
Mutations of the p53 tumour-suppressor gene are considered to be rare in human colorectal adenomas, a premalignant state of the digestive tract. We have analysed a series of 32 exophytic tumours of the colon and rectum for the presence of p53 protein. In 26 of the 28 pure adenomas, the presence o...
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