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Article

Elevated expression of p53 in early colon polyps in a pig model of human familial adenomatous polyposis.

Journal of applied genetics - 1 Nov 2018

Sikorska Agata, Flisikowska Tatiana, Stachowiak Monika, Kind Alexander, Schnieke Angelika, Flisikowski Krzysztof, Switonski Marek

Abstract excerpt

Familial adenomatous polyposis (FAP) is a hereditary predisposition to formation of colon polyps that can progress to colorectal cancer (CRC). The severity of polyposis varies substantially within families bearing the same germline mutation in the adenomatous polyposis coli (APC) tumour suppressor gene. The progressive step-wise accumulation of genetic events in tumour suppressor genes and oncogenes leads to...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 30145695
DOI: 10.1007/s13353-018-0461-6

Genes

APC
FAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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