Article
Comparison of three CYP2D6 probe substrates and genotype in Ghanaians, Chinese and Caucasians.
Pharmacogenetics - 1 Aug 1998
Droll K, Bruce-Mensah K, Otton S V, Gaedigk A, Sellers E M, Tyndale R F
Abstract excerpt
The ability to metabolize CYP2D6 substrates sparteine, debrisoquine, and dextromethorphan was studied in healthy Caucasian (n = 20), Ghanaian (n = 21), and Chinese (n = 22) CYP2D6 extensive metabolizers. Genotype analysis for the CYP2D6*1, *3, *4, *5, *9, *10, and *17 alleles was performed. Interethnic differences in the disposition of the probe drugs were found among the extensive metabolizers; extensive...
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