Article
Comparison of three CYP2D6 probe substrates and genotype in Ghanaians, Chinese and Caucasians.
Pharmacogenetics - 1 Aug 1998
Droll K, Bruce-Mensah K, Otton S V, Gaedigk A, Sellers E M, Tyndale R F
Abstract excerpt
The ability to metabolize CYP2D6 substrates sparteine, debrisoquine, and dextromethorphan was studied in healthy Caucasian (n = 20), Ghanaian (n = 21), and Chinese (n = 22) CYP2D6 extensive metabolizers. Genotype analysis for the CYP2D6*1, *3, *4, *5, *9, *10, and *17 alleles was performed. Inter...
Topics
- Adult
- Aged
- Alleles
- Asian People
- Black People
- Cross-Over Studies
- Cytochrome P-450 CYP2D6
- Debrisoquin
- Dextromethorphan
- Female
- Gene Frequency
- Genotype
- Humans
- Male
- Middle Aged
- Phenotype
- Sparteine
- Substrate Specificity