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Article

Identification and characterization of CYP2D6*56B, an allele associated with the poor metabolizer phenotype.

Clinical pharmacology and therapeutics - 1 Jun 2007

Gaedigk A, Eklund J D, Pearce R E, Leeder J S, Alander S W, Phillips M S, Bradford L D, Kennedy M J

Abstract excerpt

A 5-year-old African-American girl presented with a CYP2D6*4xN/*10 genotype that was discordant with her poor metabolizer phenotype determined with the probe drug dextromethorphan. Both phenotype and genotype were confirmed in repeat assessments, suggesting that the CYP2D6*10 allele carried a novel debilitating sequence variation(s). The rationale for this study was to resolve the discordance and to describe the...

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Source

Identifiers

PMID: 17392730
DOI: 10.1038/sj.clpt.6100125

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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