Article
CYP2D6 genotyping analysis and functional characterization of novel allelic variants in a Ni-Vanuatu and Kenyan population by assessing dextromethorphan O-demethylation activity.
Drug metabolism and pharmacokinetics - 1 Feb 2020
Gutiérrez Rico Evelyn Marie, Kikuchi Aoi, Saito Takahiro, Kumondai Masaki, Hishinuma Eiji, Kaneko Akira, Chan Chim Wai, Gitaka Jesse, Nakayoshi Tomoki, Oda Akifumi, Saito Sakae, Hirasawa Noriyasu, Hiratsuka Masahiro
Abstract excerpt
While CYP2D6 allele and phenotype frequencies have been extensively studied, currently, very little ethnically specific data is available regarding the East African and South Pacific region, including Kenya and Vanuatu. The absence of information regarding gene polymorphisms and their resulting clinical effects in these populations may hinder treatment strategies and patient outcome. Given the scarceness of...
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