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Article

Analysis of the CYP2D6 gene mutations and their consequences for enzyme function in a West African population.

Pharmacogenetics - 1 Dec 1999

Griese E U, Asante-Poku S, Ofori-Adjei D, Mikus G, Eichelbaum M

Abstract excerpt

The data on differences in the metabolic handling of the CYP2D6 probe drugs sparteine and debrisoquine, and the relationship between phenotype and genotype and gene frequencies for several mutant CYP2D6 alleles in African populations are limited and sometimes controversial. Therefore, in a West African population (Ghana), we investigated (i) the phenotype for sparteine debrisoquine by phenotyping 201 individuals...

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PMID: 10634134

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