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Article

The African-specific CYP2D617 allele encodes an enzyme with changed substrate specificity.

Clinical pharmacology and therapeutics - 1 Jan 2002

Wennerholm Agneta, Dandara Collet, Sayi Jane, Svensson Jan-Olov, Abdi Yakoub Aden, Ingelman-Sundberg Magnus, Bertilsson Leif, Hasler Julia, Gustafsson Lars L

Abstract excerpt

OBJECTIVE: The effects of the CYP2D6*17 and *29 alleles on substrate specificity and enzyme activity were studied by correlating CYP2D6 genotype to phenotype with 4 probe drugs (codeine, debrisoquine, dextromethorphan, metoprolol) in black Tanzanians and white Swedes. METHODS: The black Tanzanian subjects represented the following 6 genotypic groups: A, (CYP2D6*1 or *2)/(*1 or *2) (n = 13); B, CYP2D6*17 /*17 (n =...

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Identifiers

PMID: 11823760
DOI: 10.1067/mcp.2002.120239

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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