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Article

Effects of RIalpha overexpression on cisplatin sensitivity in human ovarian carcinoma cells.

Biochemical and biophysical research communications - 28 Aug 1998

Cvijic M E, Chin K V

Abstract excerpt

Our laboratory has found that Chinese hamster ovary (CHO) and mouse Y1 adrenocortical carcinoma PKA mutants with a defective R subunit, but not altered C subunits, exhibit increased resistance to cisplatin as well as other DNA-damaging agents. The mechanism of resistance may be associated with increased recognition of the cisplatin-damaged DNA and protein binding to the DNA lesion, thus enhancing DNA repair in...

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Identifiers

PMID: 9731205
DOI: 10.1006/bbrc.1998.9223

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