Article
Effects of RIalpha overexpression on cisplatin sensitivity in human ovarian carcinoma cells.
Biochemical and biophysical research communications - 28 Aug 1998
Cvijic M E, Chin K V
Abstract excerpt
Our laboratory has found that Chinese hamster ovary (CHO) and mouse Y1 adrenocortical carcinoma PKA mutants with a defective R subunit, but not altered C subunits, exhibit increased resistance to cisplatin as well as other DNA-damaging agents. The mechanism of resistance may be associated with in...
Topics
- Animals
- Antineoplastic Agents
- CHO Cells
- Cisplatin
- Cricetinae
- Cyclic AMP-Dependent Protein Kinase RIalpha Subunit
- Cyclic AMP-Dependent Protein Kinases
- DNA Damage
- DNA Repair
- Drug Resistance
- Female
- Gene Expression
- Humans
- Mice
- Mutation
- Ovarian Neoplasms
- Protein Conformation
- Tumor Cells, Cultured