Overexpression of RII beta regulatory subunit of protein kinase A in human colon carcinoma cell induces growth arrest and phenotypic changes that are abolished by site-directed mutation of RII beta.

Abstract excerpt

LS-174T human colon carcinoma cells that contain approximately equal amounts of cAMP-dependent protein kinase (PKA) isozymes, PKA-I and PKA-II, were infected with retroviral vectors coding for regulatory (R) and catalytic (C) subunits of human PKA. In cells overexpressing RII alpha, RII beta and...

Topics

• Animals
• Base Sequence
• Carrier Proteins
• Cell Division
• Colonic Neoplasms
• Culture Media, Serum-Free
• Humans
• Intracellular Signaling Peptides and Proteins
• Isoenzymes
• Mice
• Molecular Sequence Data