Tumor reversion: protein kinase A isozyme switching.

doi:10.1196/annals.1359.014

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Article

Tumor reversion: protein kinase A isozyme switching.

Annals of the New York Academy of Sciences - 1 Nov 2005

Cho-Chung Yoon S, Nesterova Maria V

Abstract excerpt

The regulatory subunit of cAMP-dependent protein kinase (PKA) exists in the isoforms RI and RII, which distinguish PKA isozymes type I (PKA-I) and type II (PKA-II). Evidence obtained from different experimental approaches-such as site-selective cAMP analogs, antisense oligonucleotides, transcription factor decoys, cDNA microarrays, and gene transfer-has shown that PKA-I and -II are expressed in a balance of cell...

Topics

8-Bromo Cyclic Adenosine Monophosphate
Animals
Cyclic AMP
Cyclic AMP-Dependent Protein Kinase Type II
Cyclic AMP-Dependent Protein Kinases
Gene Expression Regulation, Neoplastic
Gene Transfer Techniques
Genetic Therapy
Humans
Neoplasms
Oligonucleotide Array Sequence Analysis
Oligonucleotides, Antisense
Phenotype
Protein Isoforms

Source

Open in PubMed

Identifiers

PMID: 16394127
DOI: 10.1196/annals.1359.014

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