Article
Tumor reversion: protein kinase A isozyme switching.
Annals of the New York Academy of Sciences - 1 Nov 2005
Cho-Chung Yoon S, Nesterova Maria V
Abstract excerpt
The regulatory subunit of cAMP-dependent protein kinase (PKA) exists in the isoforms RI and RII, which distinguish PKA isozymes type I (PKA-I) and type II (PKA-II). Evidence obtained from different experimental approaches-such as site-selective cAMP analogs, antisense oligonucleotides, transcription factor decoys, cDNA microarrays, and gene transfer-has shown that PKA-I and -II are expressed in a balance of cell...
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