Transfection of a mutant regulatory subunit gene of cAMP-dependent protein kinase causes increased drug sensitivity and decreased expression of P-glycoprotein.

doi:10.1016/0014-4827(90)90265-c

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Article

Transfection of a mutant regulatory subunit gene of cAMP-dependent protein kinase causes increased drug sensitivity and decreased expression of P-glycoprotein.

Experimental cell research - 1 Jul 1990

Abraham I, Chin K V, Gottesman M M, Mayo J K, Sampson K E

Abstract excerpt

Wild-type Chinese hamster ovary (CHO) cells were transfected with a DNA clone (MT-REV, site A) carrying a mouse gene for a dominant mutant regulatory subunit (RI) gene of cAMP-dependent protein kinase (PKA) from S49 cells along with a marker for G418 resistance. G418-resistant transfectant clone...

Topics

8-Bromo Cyclic Adenosine Monophosphate
ATP Binding Cassette Transporter, Subfamily B, Member 1
Animals
Bucladesine
Carrier Proteins
Cell Line
Drug Resistance
Intracellular Signaling Peptides and Proteins
Membrane Glycoproteins
Mutation
Phenotype
Phosphorylation
Protein Kinase Inhibitors
Protein Kinases
Transcription, Genetic
Transfection

Source

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Identifiers

PMID: 1971796
DOI: 10.1016/0014-4827(90)90265-c

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1971796-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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