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Dissecting the Circuitry of Protein Kinase A and cAMP Signaling in Cancer Genesis

1 Jun 2002

Abstract excerpt

Expression of the RI alpha subunit of the cAMP-dependent protein kinase type I (PKA-I) is enhanced in human cancer cell lines, in primary tumors, in transformed cells, and in cells upon stimulation of growth. Signaling via the cAMP pathway may be complex, and the biological effects of the pathway in normal cells may depend upon the physiological state of the cells. However, results of different experimental...

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PMID: 12119265
DOI: 10.1111/j.1749-6632.2002.tb04324.x

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