IL-22 Fate Reporter Reveals Origin and Control of IL-22 Production in Homeostasis and Infection

Abstract excerpt

IL-22 is a cytokine that regulates tissue homeostasis at barrier surfaces. A variety of IL-22-producing cell types is known, but identification on the single-cell level remains difficult. Therefore, we generated a fate reporter mouse that would allow the identification of IL-22-producing cells and their fate mapping in vivo. To trace IL-22-expressing cells, a sequence encoding Cre recombinase was cloned into the...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Dermatology and Skin Diseases
• Share to IL-33, ST2, and ILC Pathways
• Share to Psoriasis: Treatment and Pathogenesis