Article
Constitutive expression of LIGHT on T cells leads to lymphocyte activation, inflammation, and tissue destruction.
Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2001
Shaikh R B, Santee S, Granger S W, Butrovich K, Cheung T, Kronenberg M, Cheroutre H, Ware C F
Abstract excerpt
LIGHT, a member of the TNF family of cytokines (homologous to lymphotoxin, exhibits inducible expression and competes with HSV glycoprotein D for herpesvirus entry mediator, a receptor expressed on T cells), is induced on activated T cells and mediates costimulatory and antitumor activity in vitro. Relatively little information is available on the in vivo effects of LIGHT expression, particularly within the T...
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