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Article

C-terminal truncation of the Sup35 protein increases the frequency of de novo generation of a prion-based [PSI+] determinant in Saccharomyces cerevisiae.

Current genetics - 1 Aug 1998

Kochneva-Pervukhova N V, Poznyakovski A I, Smirnov V N, Ter-Avanesyan M D

Abstract excerpt

The yeast non-Mendelian [PSI+] determinant is presumed to be the manifestation of the aggregated prion-like state of the Sup35 protein. Plasmid-mediated amplification of the SUP35 gene greatly increases the frequency of Sup35p transition to this prion-like state. Here we show that the 3'-deletions of plasmid SUP35, leading to the C-terminal truncation of Sup35p, further increase the frequency of [PSI+] induction...

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PMID: 9724418
DOI: 10.1007/s002940050379

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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C-terminal truncation of the Sup35 protein increases the frequency of de novo generation of a prion-based [PSI+] determinant in Saccharomyces cerevisiae.PMID 9724418Read ↗

The [PSI+] prion of yeast: a problem of inheritance.Semantic proximity Read ↗

[Psi(+)] prion generation in yeast: characterization of the 'strain' difference.Semantic proximity Read ↗

Propagation of the yeast prion-like [psi+] determinant is mediated by oligomerization of the SUP35-encoded polypeptide chain release factor.Semantic proximity Read ↗

[Fusion of glutathione S-transferase with the N-terminus of yeast Sup35p protein inhibits its prion-like properties].Semantic proximity Read ↗

In vitro propagation of the prion-like state of yeast Sup35 protein.Semantic proximity Read ↗

Support for the prion hypothesis for inheritance of a phenotypic trait in yeast.Semantic proximity Read ↗

Evidence for the prion hypothesis: induction of the yeast [PSI+] factor by in vitro- converted Sup35 protein.Semantic proximity Read ↗

The role of the N-terminal oligopeptide repeats of the yeast Sup35 prion protein in propagation and transmission of prion variants.Semantic proximity Read ↗

Mechanism of inhibition of Psi+ prion determinant propagation by a mutation of the N-terminus of the yeast Sup35 protein.Semantic proximity Read ↗

Detection system- and strain-dependent diversity of de novo [PSI+] prion generation and phenotypes in Saccharomyces cerevisiae.Semantic proximity Read ↗

Supporting the structural basis of prion strains: induction and identification of [PSI] variants.Semantic proximity Read ↗

A prolonged chronological lifespan is an unexpected benefit of the [PSI+] prion in yeast.Semantic proximity Read ↗

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