Article
C-terminal truncation of the Sup35 protein increases the frequency of de novo generation of a prion-based [PSI+] determinant in Saccharomyces cerevisiae.
Current genetics - 1 Aug 1998
Kochneva-Pervukhova N V, Poznyakovski A I, Smirnov V N, Ter-Avanesyan M D
Abstract excerpt
The yeast non-Mendelian [PSI+] determinant is presumed to be the manifestation of the aggregated prion-like state of the Sup35 protein. Plasmid-mediated amplification of the SUP35 gene greatly increases the frequency of Sup35p transition to this prion-like state. Here we show that the 3'-deletion...
Topics
- Alleles
- Fungal Proteins
- Gene Amplification
- Gene Expression
- Genes, Fungal
- Peptide Termination Factors
- Plasmids
- Prions
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Sequence Deletion
- Transformation, Genetic