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Article

Supporting the structural basis of prion strains: induction and identification of [PSI] variants.

Journal of molecular biology - 13 Apr 2001

King C Y

Abstract excerpt

The [PSI] genetic element, which enhances the nonsense suppression efficiency in the yeast Saccharomyces cerevisiae, is thought to be amyloid-like aggregates of the Sup35 protein, and to self-propagate by a prion-like mechanism. Analogous to strains of the mammalian prion, variants of [PSI], with different nonsense suppression efficiencies and mitotic stabilities, can be isolated from the same yeast genetic...

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Identifiers

PMID: 11292339
DOI: 10.1006/jmbi.2001.4542

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Supporting the structural basis of prion strains: induction and identification of [PSI] variants.PMID 11292339Read ↗

[Psi(+)] prion generation in yeast: characterization of the 'strain' difference.Semantic proximity Read ↗

Inter-allelic prion propagation reveals conformational relationships among a multitude of [PSI] strains.Semantic proximity Read ↗

Strains of [PSI(+)] are distinguished by their efficiencies of prion-mediated conformational conversion.Semantic proximity Read ↗

W8, a new Sup35 prion strain, transmits distinctive information with a conserved assembly scheme.Semantic proximity Read ↗

The [PSI+] prion exists as a dynamic cloud of variants.Semantic proximity Read ↗

Detection system- and strain-dependent diversity of de novo [PSI+] prion generation and phenotypes in Saccharomyces cerevisiae.Semantic proximity Read ↗

The role of the N-terminal oligopeptide repeats of the yeast Sup35 prion protein in propagation and transmission of prion variants.Semantic proximity Read ↗

Wild yeast harbour a variety of distinct amyloid structures with strong prion-inducing capabilities.Semantic proximity Read ↗

The [PSI+] prion of yeast: a problem of inheritance.Semantic proximity Read ↗

Epigenetic regulation of translation reveals hidden genetic variation to produce complex traits.Semantic proximity Read ↗

The Sup35 domains required for maintenance of weak, strong or undifferentiated yeast [PSI+] prions.Semantic proximity Read ↗

The PNM2 mutation in the prion protein domain of SUP35 has distinct effects on different variants of the [PSI+] prion in yeast.Semantic proximity Read ↗

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