Article
[Fusion of glutathione S-transferase with the N-terminus of yeast Sup35p protein inhibits its prion-like properties].
Genetika - 1 May 1997
Dagkesamanskaia A R, Kushnirov V V, Paushkin S V, Ter-Avanesian M D
Abstract excerpt
The yeast Saccharomyces cerevisiae SUP35 gene that encodes the Sup35p protein homologous to the translation termination eRF3 factor of higher eukaryotes is essential to replication of the nonchromosomally inherited [psi+] determinant. The nonsense suppressor phenotype of this determinant was assumed to be dependent on a specific conformational state of the Sup35p protein; the transition to this state leads to...
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