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In vitro propagation of the prion-like state of yeast Sup35 protein.

Science (New York, N.Y.) - 18 Jul 1997

Paushkin S V, Kushnirov V V, Smirnov V N, Ter-Avanesyan M D

Abstract excerpt

The yeast cytoplasmically inherited genetic determinant [PSI+] is presumed to be a manifestation of the prion-like properties of the Sup35 protein (Sup35p). Here, cell-free conversion of Sup35p from [psi-] cells (Sup35ppsi-) to the prion-like [PSI+]-specific form (Sup35pPSI+) was observed. The co...

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Phenotype
Saccharomyces cerevisiae
Fungal Proteins
Protein Conformation
Saccharomyces cerevisiae Proteins
Protein Biosynthesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transformation, Genetic

Protein Folding

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Identifiers

PMID: 9219697
DOI: 10.1126/science.277.5324.381

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-9219697-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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In vitro propagation of the prion-like state of yeast Sup35 protein.PMID 9219697Read ↗

The [PSI+] prion of yeast: a problem of inheritance.Semantic proximity Read ↗

Evidence for the prion hypothesis: induction of the yeast [PSI+] factor by in vitro- converted Sup35 protein.Semantic proximity Read ↗

Propagation of the yeast prion-like [psi+] determinant is mediated by oligomerization of the SUP35-encoded polypeptide chain release factor.Semantic proximity Read ↗

Support for the prion hypothesis for inheritance of a phenotypic trait in yeast.Semantic proximity Read ↗

A prolonged chronological lifespan is an unexpected benefit of the [PSI+] prion in yeast.Semantic proximity Read ↗

C-terminal truncation of the Sup35 protein increases the frequency of de novo generation of a prion-based [PSI+] determinant in Saccharomyces cerevisiae.Semantic proximity Read ↗

The Sup35 domains required for maintenance of weak, strong or undifferentiated yeast [PSI+] prions.Semantic proximity Read ↗

The role of the N-terminal oligopeptide repeats of the yeast Sup35 prion protein in propagation and transmission of prion variants.Semantic proximity Read ↗

Effect of charged residues in the N-domain of Sup35 protein on prion [PSI+] stability and propagation.Semantic proximity Read ↗

W8, a new Sup35 prion strain, transmits distinctive information with a conserved assembly scheme.Semantic proximity Read ↗

Yeast prions assembly and propagation: contributions of the prion and non-prion moieties and the nature of assemblies.Semantic proximity Read ↗

Mechanism of inhibition of Psi+ prion determinant propagation by a mutation of the N-terminus of the yeast Sup35 protein.Semantic proximity Read ↗

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