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Article

Support for the prion hypothesis for inheritance of a phenotypic trait in yeast.

Science (New York, N.Y.) - 2 Aug 1996

Patino M M, Liu J J, Glover J R, Lindquist S

Abstract excerpt

A cytoplasmically inherited genetic element in yeast, [PSI+], was confirmed to be a prionlike aggregate of the cellular protein Sup35 by differential centrifugation analysis and microscopic localization of a Sup35-green fluorescent protein fusion. Aggregation depended on the intracellular concentration and functional state of the chaperone protein Hsp104 in the same manner as did [PSI+] inheritance. The...

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Source

Identifiers

PMID: 8662547
DOI: 10.1126/science.273.5275.622

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Support for the prion hypothesis for inheritance of a phenotypic trait in yeast.PMID 8662547Read ↗

[Psi(+)] prion generation in yeast: characterization of the 'strain' difference.Semantic proximity Read ↗

The [PSI+] prion of yeast: a problem of inheritance.Semantic proximity Read ↗

In vitro propagation of the prion-like state of yeast Sup35 protein.Semantic proximity Read ↗

Propagation of the yeast prion-like [psi+] determinant is mediated by oligomerization of the SUP35-encoded polypeptide chain release factor.Semantic proximity Read ↗

Evidence for the prion hypothesis: induction of the yeast [PSI+] factor by in vitro- converted Sup35 protein.Semantic proximity Read ↗

Supporting the structural basis of prion strains: induction and identification of [PSI] variants.Semantic proximity Read ↗

C-terminal truncation of the Sup35 protein increases the frequency of de novo generation of a prion-based [PSI+] determinant in Saccharomyces cerevisiae.Semantic proximity Read ↗

Protein-only inheritance in yeast: something to get [PSI+]-ched about.Semantic proximity Read ↗

The role of the N-terminal oligopeptide repeats of the yeast Sup35 prion protein in propagation and transmission of prion variants.Semantic proximity Read ↗

Genetic and environmental factors affecting the de novo appearance of the [PSI+] prion in Saccharomyces cerevisiae.Semantic proximity Read ↗

Role of the chaperone protein Hsp104 in propagation of the yeast prion-like factor [psi+].Semantic proximity Read ↗

[Modification of [PSI+] prion properties by the combination of amino acid changes within Sup35 protein N-domain].Semantic proximity Read ↗

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