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Article

Mechanism of inhibition of Psi+ prion determinant propagation by a mutation of the N-terminus of the yeast Sup35 protein.

The EMBO journal - 1 Oct 1998

Kochneva-Pervukhova N V, Paushkin S V, Kushnirov V V, Cox B S, Tuite M F, Ter-Avanesyan M D

Abstract excerpt

The SUP35 gene of Saccharomyces cerevisiae encodes the polypeptide chain release factor eRF3. This protein (also called Sup35p) is thought to be able to undergo a heritable conformational switch, similarly to mammalian prions, giving rise to the cytoplasmically inherited Psi+ determinant. A dominant mutation (PNM2 allele) in the SUP35 gene causing a Gly58-->Asp change in the Sup35p N-terminal domain eliminates...

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Identifiers

PMID: 9755180
DOI: 10.1093/emboj/17.19.5805
PMCID: PMC1170908

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Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Mechanism of inhibition of Psi+ prion determinant propagation by a mutation of the N-terminus of the yeast Sup35 protein.PMID 9755180Read ↗

Propagation of the yeast prion-like [psi+] determinant is mediated by oligomerization of the SUP35-encoded polypeptide chain release factor.Semantic proximity Read ↗

Nonsense Mutations in the Yeast SUP35 Gene Affect the [PSI+] Prion Propagation.Semantic proximity Read ↗

Interaction between yeast Sup45p (eRF1) and Sup35p (eRF3) polypeptide chain release factors: implications for prion-dependent regulation.Semantic proximity Read ↗

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[Modification of [PSI+] prion properties by the combination of amino acid changes within Sup35 protein N-domain].Semantic proximity Read ↗

The [PSI+] prion of yeast: a problem of inheritance.Semantic proximity Read ↗

In vitro propagation of the prion-like state of yeast Sup35 protein.Semantic proximity Read ↗

The role of the N-terminal oligopeptide repeats of the yeast Sup35 prion protein in propagation and transmission of prion variants.Semantic proximity Read ↗

C-terminal truncation of the Sup35 protein increases the frequency of de novo generation of a prion-based [PSI+] determinant in Saccharomyces cerevisiae.Semantic proximity Read ↗

The PNM2 mutation in the prion protein domain of SUP35 has distinct effects on different variants of the [PSI+] prion in yeast.Semantic proximity Read ↗

The yeast non-Mendelian factor [ETA+] is a variant of [PSI+], a prion-like form of release factor eRF3.Semantic proximity Read ↗

Evidence for the prion hypothesis: induction of the yeast [PSI+] factor by in vitro- converted Sup35 protein.Semantic proximity Read ↗

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