Mechanism of inhibition of Psi+ prion determinant propagation by a mutation of the N-terminus of the yeast Sup35 protein.

doi:10.1093/emboj/17.19.5805

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Article

Mechanism of inhibition of Psi+ prion determinant propagation by a mutation of the N-terminus of the yeast Sup35 protein.

The EMBO journal - 1 Oct 1998

Kochneva-Pervukhova N V, Paushkin S V, Kushnirov V V, Cox B S, Tuite M F, Ter-Avanesyan M D

Abstract excerpt

The SUP35 gene of Saccharomyces cerevisiae encodes the polypeptide chain release factor eRF3. This protein (also called Sup35p) is thought to be able to undergo a heritable conformational switch, similarly to mammalian prions, giving rise to the cytoplasmically inherited Psi+ determinant. A domin...

Topics

Chromosomes, Fungal
Fungal Proteins
Gene Dosage
Mutation
Peptide Termination Factors
Prions
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

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