Article
Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death.
Science (New York, N.Y.) - 25 Feb 2000
Chen F, Hersh B M, Conradt B, Zhou Z, Riemer D, Gruenbaum Y, Horvitz H R
Abstract excerpt
The Caenorhabditis elegans Bcl-2-like protein CED-9 prevents programmed cell death by antagonizing the Apaf-1-like cell-death activator CED-4. Endogenous CED-9 and CED-4 proteins localized to mitochondria in wild-type embryos, in which most cells survive. By contrast, in embryos in which cells had been induced to die, CED-4 assumed a perinuclear localization. CED-4 translocation induced by the cell-death...
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