Article
Suppression of CED-3-independent apoptosis by mitochondrial betaNAC in Caenorhabditis elegans.
Nature - 28 Aug 2003
Bloss Tim A, Witze Eric S, Rothman Joel H
Abstract excerpt
To ensure cell survival, it is essential that the ubiquitous pro-apoptotic machinery is kept quiescent. As death is irreversible, cells must continually integrate developmental information with regulatory inputs to control the switch between repressing and activating apoptosis. Inappropriate activation or suppression of apoptosis can lead to degenerative pathologies or tumorigenesis, respectively. Here we report...
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