Suppression of CED-3-independent apoptosis by mitochondrial betaNAC in Caenorhabditis elegans.

doi:10.1038/nature01920

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Article

Suppression of CED-3-independent apoptosis by mitochondrial betaNAC in Caenorhabditis elegans.

Nature - 28 Aug 2003

Bloss Tim A, Witze Eric S, Rothman Joel H

Abstract excerpt

To ensure cell survival, it is essential that the ubiquitous pro-apoptotic machinery is kept quiescent. As death is irreversible, cells must continually integrate developmental information with regulatory inputs to control the switch between repressing and activating apoptosis. Inappropriate activation or suppression of apoptosis can lead to degenerative pathologies or tumorigenesis, respectively. Here we report...

Topics

Amino Acid Sequence
Animals
Apoptosis
Apoptosis Regulatory Proteins
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Calcium-Binding Proteins
Caspases
Heat-Shock Response
Intestinal Mucosa
Intestines
Mitochondria
Molecular Chaperones
Molecular Sequence Data
Mutation
Neurons
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-bcl-2

Source

Open in PubMed

Identifiers

PMID: 12944970
DOI: 10.1038/nature01920

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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