Interaction and regulation of subcellular localization of CED-4 by CED-9.

doi:10.1126/science.275.5303.1126

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Article

Interaction and regulation of subcellular localization of CED-4 by CED-9.

Science (New York, N.Y.) - 21 Feb 1997

Wu D, Wallen H D, Nuñez G

Abstract excerpt

The Caenorhabditis elegans survival gene ced-9 regulates ced-4 activity and inhibits cell death, but the mechanism by which this occurs is unknown. Through a genetic screen for CED-4-binding proteins, CED-9 was identified as an interacting partner of CED-4. CED-9, but not loss-of-function mutants...

Topics

Animals
Apoptosis
Apoptosis Regulatory Proteins
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Calcium-Binding Proteins
Cell Fractionation
Cell Line
Cytosol
Genes, Helminth
Helminth Proteins
Humans
Intracellular Membranes
Mutation
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-bcl-2
Transfection
bcl-X Protein

Source

Open in PubMed

Identifiers

PMID: 9027313
DOI: 10.1126/science.275.5303.1126

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9027313-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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