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Article

Interaction and regulation of subcellular localization of CED-4 by CED-9.

Science (New York, N.Y.) - 21 Feb 1997

Wu D, Wallen H D, Nuñez G

Abstract excerpt

The Caenorhabditis elegans survival gene ced-9 regulates ced-4 activity and inhibits cell death, but the mechanism by which this occurs is unknown. Through a genetic screen for CED-4-binding proteins, CED-9 was identified as an interacting partner of CED-4. CED-9, but not loss-of-function mutants, associated specifically with CED-4 in yeast or mammalian cells. The CED-9 protein localized primarily to...

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Identifiers

PMID: 9027313
DOI: 10.1126/science.275.5303.1126

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