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Influence of Human Leukocyte Antigen (HLA) Alleles and Killer Cell Immunoglobulin-Like Receptors (KIR) Types on Heparin-Induced Thrombocytopenia (HIT).

Pharmacotherapy - 1 Sept 2017

Karnes Jason H, Shaffer Christian M, Cronin Robert, Bastarache Lisa, Gaudieri Silvana, James Ian, Pavlos Rebecca, Steiner Heidi E, Mosley Jonathan D, Mallal Simon, Denny Joshua C, Phillips Elizabeth J, Roden Dan M

Abstract excerpt

Heparin-induced thrombocytopenia (HIT) is an unpredictable, life-threatening, immune-mediated reaction to heparin. Variation in human leukocyte antigen (HLA) genes is now used to prevent immune-mediated adverse drug reactions. Combinations of HLA alleles and killer cell immunoglobulin-like receptors (KIR) are associated with multiple autoimmune diseases and infections. The objective of this study is to evaluate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28688202
DOI: 10.1002/phar.1983
PMCID: PMC5600645

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