Article
A genome-wide association study of heparin-induced thrombocytopenia using an electronic medical record.
Thrombosis and haemostasis - 1 Apr 2015
Karnes Jason H, Cronin Robert M, Rollin Jerome, Teumer Alexander, Pouplard Claire, Shaffer Christian M, Blanquicett Carmelo, Bowton Erica A, Cowan James D, Mosley Jonathan D, Van Driest Sara L, Weeke Peter E, Wells Quinn S, Bakchoul Tamam, Denny Joshua C, Greinacher Andreas, Gruel Yves, Roden Dan M
Abstract excerpt
Heparin-induced thrombocytopenia (HIT) is an unpredictable, potentially catastrophic adverse effect of heparin treatment resulting from an immune response to platelet factor 4 (PF4)/heparin complexes. No genome-wide evaluations have been performed to identify potential genetic influences on HIT. Here, we performed a genome-wide association study (GWAS) and candidate gene study using HIT cases and controls...
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