Article
Topical retinoic acid reduces skin papilloma formation but resistant papillomas are at high risk for malignant conversion.
Cancer research - 1 Apr 1998
Tennenbaum T, Lowry D, Darwiche N, Morgan D L, Gartsbein M, Hansen L, De Luca L M, Hennings H, Yuspa S H
Abstract excerpt
Retinoic acid (RA) was topically applied to the skin of Sencar mice during the promotion phase of specific tumor induction protocols that produce papillomas at low (12-O-tetradecanoylphorbol-13-acetate promoted, TPA) or high (mezerein-promoted) risk for premalignant progression and malignant conversion. RA consistently reduced the yield of papillomas and carcinomas in both protocols, but the frequency of...
Topics
- Administration, Topical
- Animals
- Anticarcinogenic Agents
- Antineoplastic Agents
- Biomarkers, Tumor
- Carcinogens
- Carcinoma, Basal Cell
- Cell Transformation, Neoplastic
- Disease Progression
- Diterpenes
- Female
- Immunohistochemistry
- Mice