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Article

Topical retinoic acid reduces skin papilloma formation but resistant papillomas are at high risk for malignant conversion.

Cancer research - 1 Apr 1998

Tennenbaum T, Lowry D, Darwiche N, Morgan D L, Gartsbein M, Hansen L, De Luca L M, Hennings H, Yuspa S H

Abstract excerpt

Retinoic acid (RA) was topically applied to the skin of Sencar mice during the promotion phase of specific tumor induction protocols that produce papillomas at low (12-O-tetradecanoylphorbol-13-acetate promoted, TPA) or high (mezerein-promoted) risk for premalignant progression and malignant conversion. RA consistently reduced the yield of papillomas and carcinomas in both protocols, but the frequency of...

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PMID: 9537245

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Topical retinoic acid reduces skin papilloma formation but resistant papillomas are at high risk for malignant conversion.PMID 9537245Read ↗

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Transgenic overexpression of transforming growth factor alpha bypasses the need for c-Ha-ras mutations in mouse skin tumorigenesis.Semantic proximity Read ↗

Only a subset of 12-O-tetradecanoylphorbol-13-acetate-promoted mouse skin papillomas are promotable by benzoyl peroxide.Semantic proximity Read ↗

Lack of effect of retinoic acid and fluocinolone acetonide on mirex tumor promotion indicates a novel mirex mechanism.Semantic proximity Read ↗

Evidence that mirex promotes a unique population of epidermal cells that cannot be distinguished by their mutant Ha-ras genotype.Semantic proximity Read ↗

Papillomas induced by initiation-promotion differ from those induced by carcinogen alone.Semantic proximity Read ↗

Promoter independence as a feature of most skin papillomas in SENCAR mice.Semantic proximity Read ↗

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