Autocrine transforming growth factor alpha is dispensible for v-rasHa-induced epidermal neoplasia: potential involvement of alternate epidermal growth factor receptor ligands.

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Article

Autocrine transforming growth factor alpha is dispensible for v-rasHa-induced epidermal neoplasia: potential involvement of alternate epidermal growth factor receptor ligands.

Cancer research - 1 May 1995

Dlugosz A A, Cheng C, Williams E K, Darwiche N, Dempsey P J, Mann B, Dunn A R, Coffey R J, Yuspa S H

Abstract excerpt

Autocrine epidermal growth factor receptor activation by transforming growth factor alpha (TGF alpha) has been implicated in growth stimulation during epithelial neoplasia. Using keratinocytes isolated from mice with genetic defects in TGF alpha expression, we tested whether TGF alpha is required for transformation by the v-rasHa oncogene. Introduction of v-rasHa into primary epidermal cultures using a retroviral...

Topics

Animals
Cell Division
Cell Transformation, Neoplastic
ErbB Receptors
Gene Expression Regulation, Neoplastic
Genes, ras
Keratinocytes
Ligands
Mice
Mice, Inbred BALB C

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Nude

Papilloma

Phenotype

Skin Neoplasms

Transcription, Genetic

Transforming Growth Factor alpha

Source

Open in PubMed

Identifiers

PMID: 7728756

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7728756-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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