Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Variable heavy chain gene analysis of follicular lymphomas: correlation between heavy chain isotype expression and somatic mutation load.

Blood - 1 May 2000

Aarts W M, Bende R J, Steenbergen E J, Kluin P M, Ooms E C, Pals S T, van Noesel C J

Abstract excerpt

The expansion of follicular lymphomas (FLs) resembles, both morphologically and functionally, normal germinal center B-cell growth. The tumor cells proliferate in networks of follicular dendritic cells and are believed to be capable of somatic hypermutation and isotype switching. To investigate the relation between somatic mutation and heavy chain isotype expression, we analyzed the variable heavy (V(H)) chain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genes, Immunoglobulin
Share to Immunoglobulin Heavy Chains

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunoglobulin Isotypes

Share to Immunoglobulin M

Share to Immunoglobulin Switch Region

Share to Immunoglobulin Variable Region

Share to Lymph Nodes

Share to Lymphoma, Follicular

Source

Identifiers

PMID: 10779440

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variable heavy chain gene analysis of follicular lymphomas: correlation between heavy chain isotype expression and somatic mutation load.PMID 10779440Read ↗

The genetic variability of the VH genes in follicular lymphoma: the impact of the hypermutation mechanism.Semantic proximity Read ↗

High Throughput Sequencing Analysis of the Immunoglobulin Heavy Chain Gene from Flow-Sorted B Cell Sub-Populations Define the Dynamics of Follicular Lymphoma Clonal Evolution.Semantic proximity Read ↗

VH gene analysis of primary cutaneous B-cell lymphomas: evidence for ongoing somatic hypermutation and isotype switching.Semantic proximity Read ↗

Somatic hypermutation of immunoglobulin variable region genes: focus on follicular lymphoma and multiple myeloma.Semantic proximity Read ↗

VH and VL gene analysis in sporadic Burkitt's lymphoma shows somatic hypermutation, intraclonal heterogeneity, and a role for antigen selection.Semantic proximity Read ↗

Analysis of VH genes in follicular and diffuse lymphoma shows ongoing somatic mutation and multiple isotype transcripts in early disease with changes during disease progression.Semantic proximity Read ↗

Re-entry of tumour B cells into the cycle of somatic mutation and isotype switching in follicular lymphoma.Semantic proximity Read ↗

VH gene analysis in sporadic Burkitt's lymphoma: somatic mutation and intraclonal diversity with special reference to the tumor cells involving germinal center.Semantic proximity Read ↗

Acquisition of potential N-glycosylation sites in the immunoglobulin variable region by somatic mutation is a distinctive feature of follicular lymphoma.Semantic proximity Read ↗

Progressive immunoglobulin gene mutations in chronic lymphocytic leukemia: evidence for antigen-driven intraclonal diversification.Semantic proximity Read ↗

Analysis of variable heavy and light chain genes in follicular lymphomas of different heavy chain isotype.Semantic proximity Read ↗

IgV(H) and bcl6 somatic mutation analysis reveals the heterogeneity of cutaneous B-cell lymphoma, and indicates the presence of undisclosed local antigens.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.