Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

VH and VL gene analysis in sporadic Burkitt's lymphoma shows somatic hypermutation, intraclonal heterogeneity, and a role for antigen selection.

Blood - 1 Nov 1996

Chapman C J, Zhou J X, Gregory C, Rickinson A B, Stevenson F K

Abstract excerpt

Tumor cell lines and one tumor biopsy from seven cases of Epstein-Barr virus (EBV) genome-negative sporadic Burkitt's lymphoma (BL) have been investigated for usage and mutational pattern of Ig variable region genes. The VH genes were derived from the VH 3 (one) and VH4 (six) families and both the IgM-positive (six) and the IgA-positive (one) were all mutated from their germline counterparts. The VL genes were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Amino Acid Sequence
Share to Genes, Immunoglobulin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunoglobulin Variable Region

Share to Molecular Sequence Data

Share to Mutation

Share to Sequence Analysis

Source

Identifiers

PMID: 8896424

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

VH and VL gene analysis in sporadic Burkitt's lymphoma shows somatic hypermutation, intraclonal heterogeneity, and a role for antigen selection.PMID 8896424Read ↗

Analysis of VH genes used by neoplastic B cells in endemic Burkitt's lymphoma shows somatic hypermutation and intraclonal heterogeneity.Semantic proximity Read ↗

Insight into Burkitt's lymphoma from immunoglobulin variable region gene analysis.Semantic proximity Read ↗

VH gene analysis in sporadic Burkitt's lymphoma: somatic mutation and intraclonal diversity with special reference to the tumor cells involving germinal center.Semantic proximity Read ↗

Burkitt's lymphoma is a malignancy of mature B cells expressing somatically mutated V region genes.Semantic proximity Read ↗

Analysis of VH genes in follicular and diffuse lymphoma shows ongoing somatic mutation and multiple isotype transcripts in early disease with changes during disease progression.Semantic proximity Read ↗

Analysis of expressed immunoglobulin heavy chain genes in familial B-CLL.Semantic proximity Read ↗

VH gene analysis of primary cutaneous B-cell lymphomas: evidence for ongoing somatic hypermutation and isotype switching.Semantic proximity Read ↗

V(H) gene analysis of Burkitt's lymphoma in children from north-western Iran.Semantic proximity Read ↗

Variable heavy chain gene analysis of follicular lymphomas: correlation between heavy chain isotype expression and somatic mutation load.Semantic proximity Read ↗

Burkitt's lymphomas express VH genes with a moderate number of antigen-selected somatic mutations.Semantic proximity Read ↗

Splenic lymphoma with villous lymphocytes involves B cells with extensively mutated Ig heavy chain variable region genes.Semantic proximity Read ↗

Molecular analysis of immunoglobulin genes in diffuse large B-cell lymphomasSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.