VH and VL gene analysis in sporadic Burkitt's lymphoma shows somatic hypermutation, intraclonal heterogeneity, and a role for antigen selection.

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Article

VH and VL gene analysis in sporadic Burkitt's lymphoma shows somatic hypermutation, intraclonal heterogeneity, and a role for antigen selection.

Blood - 1 Nov 1996

Chapman C J, Zhou J X, Gregory C, Rickinson A B, Stevenson F K

Abstract excerpt

Tumor cell lines and one tumor biopsy from seven cases of Epstein-Barr virus (EBV) genome-negative sporadic Burkitt's lymphoma (BL) have been investigated for usage and mutational pattern of Ig variable region genes. The VH genes were derived from the VH 3 (one) and VH4 (six) families and both th...

Topics

Adolescent
Amino Acid Sequence
Animals
Antigens, Neoplasm
Burkitt Lymphoma
Female
Genes, Immunoglobulin
Humans
Immunoglobulin A
Immunoglobulin M
Immunoglobulin Variable Region
Mice
Molecular Sequence Data
Mutation
Sequence Analysis

Source

Open in PubMed

Identifiers

PMID: 8896424

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8896424-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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