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Article

Burkitt's lymphoma is a malignancy of mature B cells expressing somatically mutated V region genes.

Molecular medicine (Cambridge, Mass.) - 1 Jul 1995

Klein U, Klein G, Ehlin-Henriksson B, Rajewsky K, Küppers R

Abstract excerpt

BACKGROUND: The developmental stage from which stems the malignant B cell population in Burkitt's lymphoma (BL) is unclear. An approach to answering this question is provided by the sequence analysis of rear-ranged immunoglobulin (Ig) variable region (V) genes from BL for evidence of somatic mutations, together with a phenotypic characterization. As somatic hypermutation of Ig V region genes occurs in germinal...

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Identifiers

PMID: 8529116
PMCID: PMC2229966

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Burkitt's lymphoma is a malignancy of mature B cells expressing somatically mutated V region genes.PMID 8529116Read ↗

Burkitt's lymphomas express VH genes with a moderate number of antigen-selected somatic mutations.Semantic proximity Read ↗

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Insight into Burkitt's lymphoma from immunoglobulin variable region gene analysis.Semantic proximity Read ↗

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Molecular analysis of single B cells from T-cell-rich B-cell lymphoma shows the derivation of the tumor cells from mutating germinal center B cells and exemplifies means by which immunoglobulin genes are modified in germinal center B cells.Semantic proximity Read ↗

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Analysis of VH genes used by neoplastic B cells in endemic Burkitt's lymphoma shows somatic hypermutation and intraclonal heterogeneity.Semantic proximity Read ↗

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