Article
Localization of the MEN1 gene to a small region within chromosome 11q13 by deletion mapping in tumors.
Proceedings of the National Academy of Sciences of the United States of America - 1 Mar 1990
Byström C, Larsson C, Blomberg C, Sandelin K, Falkmer U, Skogseid B, Oberg K, Werner S, Nordenskjöld M
Abstract excerpt
The gene for multiple endocrine neoplasia type 1 (MEN1), an inherited predisposition to neuroendocrine neoplasm of the parathyroid glands, the pancreatic islet parenchyma, and the anterior pituitary gland, was recently mapped to chromosome 11q13 based on genetic linkage in families. We now show that the pathogenesis of MEN1-associated parathyroid lesions involves unmasking of a recessive mutation at the disease...
Topics
- Adenoma
- Adult
- Aged
- Alleles
- Chromosome Deletion
- Chromosome Mapping
- Chromosomes, Human, Pair 11
- Female
- Genes
- Genetic Carrier Screening
- Humans