Article
Localization of the multiple endocrine neoplasia type I (MEN1) gene based on tumor loss of heterozygosity analysis.
Cancer research - 15 May 1997
Emmert-Buck M R, Lubensky I A, Dong Q, Manickam P, Guru S C, Kester M B, Olufemi S E, Agarwal S, Burns A L, Spiegel A M, Collins F S, Marx S J, Zhuang Z, Liotta L A, Chandrasekharappa S C, Debelenko L V
Abstract excerpt
Multiple endocrine neoplasia type I (MEN1) is an inherited syndrome that results in parathyroid, anterior pituitary, and pancreatic and duodenal endocrine tumors as well as foregut carcinoids in affected patients. The gene responsible for the disease has been linked to chromosome 11q13. We analyz...
Topics
- Alleles
- Chromosome Mapping
- Chromosomes, Human, Pair 11
- Gene Deletion
- Heterozygote
- Humans
- Multiple Endocrine Neoplasia Type 1
- Neuroendocrine Tumors