Article
Alterations of the MEN1 gene in sporadic parathyroid tumors.
The Journal of clinical endocrinology and metabolism - 1 Aug 1998
Farnebo F, Teh B T, Kytölä S, Svensson A, Phelan C, Sandelin K, Thompson N W, Höög A, Weber G, Farnebo L O, Larsson C
Abstract excerpt
Primary hyperparathyroidism is a common endocrine disease that also occurs in a number of inherited disorders, including multiple endocrine neoplasia type 1 (MEN1). Loss of heterozygosity (LOH) in the MEN1 region on chromosome 11q13 has been found in 30% of sporadic parathyroid tumors, making the...
Topics
- Adult
- Aged
- Aged, 80 and over
- Autoradiography
- Chromosomes, Human, Pair 11
- Female
- Humans
- In Situ Hybridization
- Loss of Heterozygosity
- Male
- Middle Aged
- Multiple Endocrine Neoplasia Type 1
- Mutation
- Parathyroid Neoplasms
- Polymorphism, Single-Stranded Conformational
- RNA, Messenger