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Article

Somatic mutations of multiple endocrine neoplasia type 1 gene in the sporadic endocrine tumors.

Laboratory investigation; a journal of technical methods and pathology - 1 Apr 1998

Shan L, Nakamura Y, Nakamura M, Yokoi T, Tsujimoto M, Arima R, Kameya T, Kakudo K

Abstract excerpt

Endocrine tumors of the parathyroid and pancreas are encountered either as sporadic type or as part of multiple endocrine neoplasia type 1 (MEN 1). A high frequency of the loss of heterozygosity (LOH) has been observed in tumors of the sporadic type in the locus of the MEN 1 gene, which has recently been cloned and designated the menin gene. It would be of great interest to determine whether somatic mutations in...

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PMID: 9564891

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