Article
Somatic mutation of the MEN1 gene in parathyroid tumours.
Nature genetics - 1 Aug 1997
Heppner C, Kester M B, Agarwal S K, Debelenko L V, Emmert-Buck M R, Guru S C, Manickam P, Olufemi S E, Skarulis M C, Doppman J L, Alexander R H, Kim Y S, Saggar S K, Lubensky I A, Zhuang Z, Liotta L A, Chandrasekharappa S C, Collins F S, Spiegel A M, Burns A L, Marx S J
Abstract excerpt
Primary hyperparathyroidism is a common disorder with an annual incidence of approximately 0.5 in 1,000 (ref. 1). In more than 95% of cases, the disease is caused by sporadic parathyroid adenoma or sporadic hyperplasia. Some cases are caused by inherited syndromes, such as multiple endocrine neoplasia type 1 (MEN1; ref. 2). In most cases, the molecular basis of parathyroid neoplasia is unknown. Parathyroid...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.