Article
Parathyroid MEN1 gene mutations in relation to clinical characteristics of nonfamilial primary hyperparathyroidism.
The Journal of clinical endocrinology and metabolism - 1 Aug 1998
Carling T, Correa P, Hessman O, Hedberg J, Skogseid B, Lindberg D, Rastad J, Westin G, Akerström G
Abstract excerpt
Biochemical signs and severity of symptoms of primary hyperparathyroidism (pHPT) differ among patients, and little is known of any coupling of clinical characteristics of nonfamilial pHPT to genetic abnormalities in the parathyroid tumors. Mutations in the recently identified MEN1 gene at chromos...
Topics
- Adenoma
- Aged
- Aged, 80 and over
- Chromosomes, Human, Pair 11
- Female
- Frameshift Mutation
- Gene Deletion
- Humans
- Hyperparathyroidism
- Loss of Heterozygosity
- Male
- Microsatellite Repeats
- Middle Aged
- Multiple Endocrine Neoplasia Type 1
- Mutation