Article
Rent1, a trans-effector of nonsense-mediated mRNA decay, is essential for mammalian embryonic viability.
Human molecular genetics - 15 Jan 2001
Medghalchi S M, Frischmeyer P A, Mendell J T, Kelly A G, Lawler A M, Dietz H C
Abstract excerpt
The ability to detect and degrade transcripts that lack full coding potential is ubiquitous but non-essential in lower eukaryotes, leaving in question the evolutionary basis for complete maintenance of this function. One hypothesis holds that nonsense-mediated RNA decay (NMD) protects the organism by preventing the translation of truncated peptides with dominant negative or deleterious gain-of-function potential....
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