Article
Induction of early B cell factor (EBF) and multiple B lineage genes by the basic helix-loop-helix transcription factor E12.
The Journal of experimental medicine - 17 Aug 1998
Kee B L, Murre C
Abstract excerpt
The transcription factors encoded by the E2A and early B cell factor (EBF) genes are required for the proper development of B lymphocytes. However, the absence of B lineage cells in E2A- and EBF-deficient mice has made it difficult to determine the function or relationship between these proteins....
Topics
- Animals
- Antigens, CD
- B-Lymphocytes
- Binding Sites
- Cell Line
- Cell Lineage
- Cell Membrane
- DNA-Binding Proteins
- Gene Expression Regulation
- Helix-Loop-Helix Motifs
- Hematopoietic Stem Cells
- Homeodomain Proteins
- Humans
- Immunoglobulin Light Chains
- Immunoglobulin Light Chains, Surrogate
- Immunoglobulin kappa-Chains
- Immunoglobulin mu-Chains
- Inhibitor of Differentiation Protein 2