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Article

Essential role for the transcription factor Bhlhe41 in regulating the development, self-renewal and BCR repertoire of B-1a cells.

Nature immunology - 1 Apr 2017

Kreslavsky Taras, Vilagos Bojan, Tagoh Hiromi, Poliakova Daniela Kostanova, Schwickert Tanja A, Wöhner Miriam, Jaritz Markus, Weiss Siegfried, Taneja Reshma, Rossner Moritz J, Busslinger Meinrad

Abstract excerpt

Innate-like B-1a cells provide a first line of defense against pathogens, yet little is known about their transcriptional control. Here we identified an essential role for the transcription factor Bhlhe41, with a lesser contribution by Bhlhe40, in controlling B-1a cell differentiation. Bhlhe41-/-Bhlhe40-/- B-1a cells were present at much lower abundance than were their wild-type counterparts. Mutant B-1a cells...

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Identifiers

PMID: 28250425
DOI: 10.1038/ni.3694
PMCID: PMC5363839

Genes

BCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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