Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional replacement of the mouse E2A gene with a human HEB cDNA.

Molecular and cellular biology - 1 Jun 1998

Zhuang Y, Barndt R J, Pan L, Kelley R, Dai M

Abstract excerpt

The mammalian E2A, HEB, and E2-2 genes encode a unique class of basic helix-loop-helix (bHLH) transcription factors that are evolutionarily conserved and essential for embryonic and postnatal development. While the structural and functional similarities among the gene products are well demonstrated, it is not clear why deletion of E2A, but not HEB or E2-2, leads to a complete arrest in B-lymphocyte development....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to DNA-Binding Proteins
Share to DNA, Complementary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Flow Cytometry

Share to Homozygote

Share to Mutagenesis, Site-Directed

Share to Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 9584174
DOI: 10.1128/MCB.18.6.3340
PMCID: PMC108915

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional replacement of the mouse E2A gene with a human HEB cDNA.PMID 9584174Read ↗

Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB.Semantic proximity Read ↗

The basic helix-loop-helix transcription factor E2-2 is involved in T lymphocyte development.Semantic proximity Read ↗

High incidence of T-cell tumors in E2A-null mice and E2A/Id1 double-knockout mice.Semantic proximity Read ↗

E2A and HEB are required to block thymocyte proliferation prior to pre-TCR expression.Semantic proximity Read ↗

Regulation of E2A gene expression in B-lymphocyte development.Semantic proximity Read ↗

A tamoxifen inducible knock-in allele for investigation of E2A function.Semantic proximity Read ↗

E2A Deficiency Leads to Abnormalities in αβ T-Cell Development and to Rapid Development of T-Cell LymphomasSemantic proximity Read ↗

Disruption of pre-TCR expression accelerates lymphomagenesis in E2A-deficient mice.Semantic proximity Read ↗

E2A proteins: regulators of cell phenotype in normal physiology and disease.Semantic proximity Read ↗

An Analysis of T Cell Intrinsic Roles of E2A by Conditional Gene Disruption in the ThymusSemantic proximity Read ↗

The E-Id Protein Axis Specifies Adaptive Lymphoid Cell Identity and Suppresses Thymic Innate Lymphoid Cell Development.Semantic proximity Read ↗

Mouse models in the study of the Ets family of transcription factors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.