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Article

Early B-cell factor 1 regulates the expansion of B-cell progenitors in a dose-dependent manner.

The Journal of biological chemistry - 15 Nov 2013

Åhsberg Josefine, Ungerbäck Jonas, Strid Tobias, Welinder Eva, Stjernberg Jenny, Larsson Malin, Qian Hong, Sigvardsson Mikael

Abstract excerpt

Transcription factor doses are of importance for normal and malignant B-lymphocyte development; however, the understanding of underlying mechanisms and functional consequences of reduced transcription factor levels is limited. We have analyzed progenitor and B-lineage compartments in mice carrying heterozygote mutations in the E2a, Ebf1, or Pax5 gene. Although lymphoid progenitors from Ebf1 or Pax5 heterozygote...

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Identifiers

PMID: 24078629
DOI: 10.1074/jbc.M113.506261
PMCID: PMC3829190

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BCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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