Article
differential roles for the E2A activation domains in B lymphocytes and macrophages.
Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2008
Bhalla Savita, Spaulding Christina, Brumbaugh Rachel L, Zagort Derek E, Massari Mark E, Murre Cornelis, Kee Barbara L
Abstract excerpt
The E2A gene encodes two E protein/class I basic helix-loop-helix transcription factors, E12 and E47, that are essential for B lymphopoiesis. In addition to the DNA-binding and protein dimerization domain, the E proteins share two highly conserved transcription activation domains. In this study, we show that both activation domains are required for optimal E2A-dependent transcription. Surprisingly, however,...
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