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Article

RNA unwinding in U4/U6 snRNPs requires ATP hydrolysis and the DEIH-box splicing factor Brr2.

Current biology : CB - 16 Jul 1998

Raghunathan P L, Guthrie C

Abstract excerpt

BACKGROUND: The dynamic rearrangements of RNA structure which occur during pre-mRNA splicing are thought to be mediated by members of the DExD/H-box family of RNA-dependent ATPases. Although three DExD/H-box splicing factors have recently been shown to unwind synthetic RNA duplexes in purified systems, in no case has the natural biological substrate been identified. A duplex RNA target of particular interest is...

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Identifiers

PMID: 9705931
DOI: 10.1016/s0960-9822(07)00345-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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RNA unwinding in U4/U6 snRNPs requires ATP hydrolysis and the DEIH-box splicing factor Brr2.PMID 9705931Read ↗

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Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome.Semantic proximity Read ↗

Usb1 controls U6 snRNP assembly through evolutionarily divergent cyclic phosphodiesterase activities.Semantic proximity Read ↗

Brr2p-mediated unwinding of U4/U6 is promoted by a mutually exclusive intra-molecular stem loop in U4 and involves destabilization of the 5’ stem-loop of U4Semantic proximity Read ↗

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