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Article

Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome.

Proceedings of the National Academy of Sciences of the United States of America - 23 Oct 2012

Santos Karine F, Jovin Sina Mozaffari, Weber Gert, Pena Vladimir, Lührmann Reinhard, Wahl Markus C

Abstract excerpt

Assembly of a spliceosome, catalyzing precursor-messenger RNA splicing, involves multiple RNA-protein remodeling steps, driven by eight conserved DEXD/H-box RNA helicases. The 250-kDa Brr2 enzyme, which is essential for U4/U6 di-small nuclear ribonucleoprotein disruption during spliceosome catalytic activation and for spliceosome disassembly, is the only member of this group that is permanently associated with...

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Identifiers

PMID: 23045696
DOI: 10.1073/pnas.1208098109
PMCID: PMC3491510

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome.PMID 23045696Read ↗

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