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Article

Mechanism for Aar2p function as a U5 snRNP assembly factor.

Genes & development - 1 Aug 2011

Weber Gert, Cristão Vanessa F, de L Alves Flavia, Santos Karine F, Holton Nicole, Rappsilber Juri, Beggs Jean D, Wahl Markus C

Abstract excerpt

Little is known about how particle-specific proteins are assembled on spliceosomal small nuclear ribonucleoproteins (snRNPs). Brr2p is a U5 snRNP-specific RNA helicase required for spliceosome catalytic activation and disassembly. In yeast, the Aar2 protein is part of a cytoplasmic precursor U5 snRNP that lacks Brr2p and is replaced by Brr2p in the nucleus. Here we show that Aar2p and Brr2p bind to different...

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Identifiers

PMID: 21764848
DOI: 10.1101/gad.635911
PMCID: PMC3182018

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Source receipt: pubmed, retrieved 7 Sept 2026.

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