Substrate-assisted mechanism of RNP disruption by the spliceosomal Brr2 RNA helicase.

doi:10.1073/pnas.1524616113

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Article

Substrate-assisted mechanism of RNP disruption by the spliceosomal Brr2 RNA helicase.

Proceedings of the National Academy of Sciences of the United States of America - 12 Jul 2016

Theuser Matthias, Höbartner Claudia, Wahl Markus C, Santos Karine F

Abstract excerpt

The Brr2 RNA helicase disrupts the U4/U6 di-small nuclear RNA-protein complex (di-snRNP) during spliceosome activation via ATP-driven translocation on the U4 snRNA strand. However, it is unclear how bound proteins influence U4/U6 unwinding, which regions of the U4/U6 duplex the helicase actively unwinds, and whether U4/U6 components are released as individual molecules or as subcomplexes. Here, we set up a...

Topics

Animals
Cell Line
Mutation
RNA Helicases
Ribonucleoprotein, U4-U6 Small Nuclear
Spodoptera

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Identifiers

PMID: 27354531
DOI: 10.1073/pnas.1524616113
PMCID: PMC4948317

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