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Article

Enhancer control of V(D)J recombination at the TCRbeta locus: differential effects on DNA cleavage and joining.

Genes & development - 1 Aug 1998

Hempel W M, Stanhope-Baker P, Mathieu N, Huang F, Schlissel M S, Ferrier P

Abstract excerpt

Deletion of the TCRbeta transcriptional enhancer (Ebeta) results in nearly complete inhibition of V(D)J recombination at the TCRbeta locus and a block in alpha beta T cell development. This result, along with previous work from many laboratories, has led to the hypothesis that transcriptional enh...

Topics

Alleles
Animals
Base Sequence
DNA
DNA Nucleotidyltransferases
DNA Primers
Enhancer Elements, Genetic
Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
Mice
Mice, Inbred C57BL
Mice, Knockout
Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Antigen, T-Cell, alpha-beta

Recombination, Genetic

T-Lymphocytes

VDJ Recombinases

Source

Open in PubMed Open full text

Identifiers

PMID: 9694796
DOI: 10.1101/gad.12.15.2305
PMCID: PMC317053

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9694796-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Enhancer control of V(D)J recombination at the TCRbeta locus: differential effects on DNA cleavage and joining.PMID 9694796Read ↗

The T cell receptor beta enhancer promotes access and pairing of Dbeta and Jbeta gene segments during V(D)J recombination.Semantic proximity Read ↗

Assessing the role of the T cell receptor beta gene enhancer in regulating coding joint formation during V(D)J recombination.Semantic proximity Read ↗

Duality of enhancer functioning mode revealed in a reduced TCR beta gene enhancer knockin mouse model.Semantic proximity Read ↗

Functional overlap in the cis-acting regulation of the V(D)J recombination at the TCRbeta locus.Semantic proximity Read ↗

Gene-targeted deletion and replacement mutations of the T-cell receptor beta-chain enhancer: the role of enhancer elements in controlling V(D)J recombination accessibility.Semantic proximity Read ↗

Disruption of the lineage restriction of TCR beta gene rearrangements.Semantic proximity Read ↗

Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development.Semantic proximity Read ↗

Biochemical and functional analyses of chromatin changes at the TCR-beta gene locus during CD4-CD8- to CD4+CD8+ thymocyte differentiation.Semantic proximity Read ↗

Increase of TCR V beta accessibility within E beta regulatory region influences its recombination frequency but not allelic exclusion.Semantic proximity Read ↗

Restrictions limiting the generation of DNA double strand breaks during chromosomal V(D)J recombination.Semantic proximity Read ↗

Turning T-cell receptor beta recombination on and off: more questions than answers.Semantic proximity Read ↗

Distinct control of the frequency and allelic exclusion of the V beta gene rearrangement at the TCR beta locus.Semantic proximity Read ↗

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