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Article

Enhancer control of V(D)J recombination at the TCRbeta locus: differential effects on DNA cleavage and joining.

Genes & development - 1 Aug 1998

Hempel W M, Stanhope-Baker P, Mathieu N, Huang F, Schlissel M S, Ferrier P

Abstract excerpt

Deletion of the TCRbeta transcriptional enhancer (Ebeta) results in nearly complete inhibition of V(D)J recombination at the TCRbeta locus and a block in alpha beta T cell development. This result, along with previous work from many laboratories, has led to the hypothesis that transcriptional enhancers affect V(D)J recombination by regulating the accessibility of the locus to the recombinase. Here we test this...

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Source

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Identifiers

PMID: 9694796
DOI: 10.1101/gad.12.15.2305
PMCID: PMC317053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Enhancer control of V(D)J recombination at the TCRbeta locus: differential effects on DNA cleavage and joining.PMID 9694796Read ↗

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