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Article

The transcriptional repressor GFI-1 antagonizes PU.1 activity through protein-protein interaction.

The Journal of biological chemistry - 2 Mar 2007

Dahl Richard, Iyer Sangeeta R, Owens Kristin S, Cuylear Dorothy D, Simon M Celeste

Abstract excerpt

Mice lacking the zinc finger transcriptional repressor protein GFI-1 are neutropenic. These mice generate abnormal immature myeloid cells exhibiting characteristics of both macrophages and granulocytes. Furthermore, Gfi-1(-/-) mice are highly susceptible to bacterial infection. Interestingly, Gfi-1(-/-) myeloid cells overexpress target genes of the PU.1 transcription factor such as the macrophage...

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Identifiers

PMID: 17197705
DOI: 10.1074/jbc.M607613200
PMCID: PMC3218793

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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