Article
Genetic instability in human T-lymphocytes.
Mutation research - 25 May 1998
Albertini R J, Nicklas J A, Skopek T R, Recio L, O'Neill J P
Abstract excerpt
Mutations arising in vivo in the hypoxanthine-guanine phosphoribosyltransferase (HPRT) gene of T-lymphocytes provide a measure of mutation induction in human somatic cells. Studies of measured background HPRT mutant frequency (MF) values show wide inter-individual variation. At the extremes are i...
Topics
- Adult
- Clone Cells
- DNA Mutational Analysis
- Female
- Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
- Histocompatibility Testing
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Mutagenesis
- Mutation
- Phenotype
- Receptors, Antigen, T-Cell, alpha-beta
- T-Lymphocytes