The effect of T-lymphocyte 'clonality' on the calculated hprt mutation frequency occurring in vivo in humans.

doi:10.1016/0165-1161(94)90052-3

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Article

The effect of T-lymphocyte 'clonality' on the calculated hprt mutation frequency occurring in vivo in humans.

Mutation research - 1 Jan 2000

O'Neill J P, Nicklas J A, Hunter T C, Batson O B, Allegretta M, Falta M T, Branda R F, Albertini R J

Abstract excerpt

The frequency of 6-thioguanine resistant (TGr) mutant T-lymphocytes arising in vivo in humans can be quantified with a cell cloning assay. However, the in vivo proliferation of T-lymphocytes that may include TGr mutant cells can distort the relationship between mutation events and the resulting frequency of mutant cells. The T-cell receptor (TCR) gene rearrangement pattern of T-cell colonies can be used as an...

Topics

Autoimmune Diseases
Carcinoma, Hepatocellular
Clone Cells
Drug Resistance
Female
Gene Rearrangement, T-Lymphocyte
Hepatitis
Humans
Hypoxanthine Phosphoribosyltransferase
Liver Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphocyte Activation

Lymphoma, T-Cell

Mutation

Ovarian Neoplasms

Reference Values

T-Lymphocytes

Thioguanine

Source

Open in PubMed

Identifiers

PMID: 7523907
DOI: 10.1016/0165-1161(94)90052-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7523907-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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